Magnetic Resonance Imaging pattern of congenital brain anomalies in the neurosurgery department of a teaching hospital in Nigeria: An initial experience
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Abstract
Context: Congenital brain anomalies are of diverse types however few are seen in clinical practice. They are associated with high morbidity and mortality; prompt diagnosis and management aid in mitigating some of their adverse effects. Magnetic resonance imaging (MRI) is ideal for imaging these conditions, especially in pediatric cases due to its lack of ionizing radiation and excellent soft-tissue delineation. Not much literature exists for Nigeria due to challenges with statistics and record keeping.
Aim: The aim of this study is to document the common congenital brain anomalies encountered using MRI in our environment.
Settings and Design: A 5-year retrospective study of all pediatric brain MRI conducted and reviewed in Lagos University Teaching Hospital. 73 pediatric brain MRI scans were reviewed.
Materials and Methods: Morphologic evaluation of all pediatric brain MRI conducted in the last 5 years (March 2012–February 2016) was reviewed, retrospectively, by three independent radiologists. Clinical presentations were also documented.
Statistical Analysis Used: Descriptive statistics was done using SPSS: PASW Statistics for Windows, Version 18.0
Results: Seventy-three pediatric brain MRI scans were conducted in the last 5 years with congenital brain anomalies seen in 19 (26.0%) of the cases. Their ages ranged from 3 months to 17 years with a mean age of 6.7 ± 6.1 years. There were 9 (47.4%) males and 10 (52.6%) females. The common anomalies are congenital hydrocephalus 7 (35%), of which aqueductal stenosis was 6 (32%), arteriovenous malformations 3 (16%), cerebral atrophy 3 (16%), and arachnoid cysts 2 (11%). Predominant clinical features were delayed developmental milestones, macrocephaly, seizures, headaches, and vomiting.
Conclusion: The common congenital brain anomalies in our environment are congenital hydrocephalus, aqueductal stenosis, arteriovenous malformations, cerebral atrophy and arachnoid cysts. MRI is useful in evaluating these anomalies; early diagnosis and prompt intervention can be offered to mitigate adverse effects.
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References
1. Shinagare A, Patil N. Imaging of congenital malformations of brain: A pictorial essay. Internet J Radiol 2007;9:1‑16.
2. Longo MG, Félix TM, Ashton‑Prolla P, Vedolin LM. Brain imaging and genetic risk in the pediatric population, Part 2: Congenital
malformations of the central nervous system. Neuroimaging Clin N Am 2015;25:53‑67.
3. Hussain S, Asghar I, Sabir MU, Chattha MN, Tarar SH, Mushtaq R, et al. Prevalence and pattern of congenital malformations among
neonates in the neonatal unit of a teaching hospital. J Pak Med Assoc 2014;64:629‑34.
4. Nzeh DA, Saidu SA, Erinle SA, Pam SD. Sonographic diagnosis of congenital brain malformations: The Ilorin experience. Niger Postgrad Med J 2006;13:57‑60.
5. Muga RO, Mumah SC, Juma PA. Congenital malformations amongst newborns in Kenya. Afr J Food Agric Nutr Dev 2009;9:814‑20.
6. Rajangam S, Devi R. Consanguinity and chromosomal abnormality in mental retardation and or multiple congenital anomalies. J Anat Soc
India 2007;56:30‑3.
7. Perveen F, Tyyab S. Frequency and pattern of distribution of congenital anomalies in the newborn and associated maternal risk factors. J Coll Physicians Surg Pak 2007;17:340‑3.
8. Bhargava R, Hahn G, Hirsch W, Kim MJ, Mentzel HJ, Olsen OE, et al. Contrast‑enhanced magnetic resonance imaging in pediatric patients: Review and recommendations for current practice. Magn Reson Insights 2013;6:95‑111.
9. Saunders DE, Thompson C, Gunny R, Jones R, Cox T, Chong WK. Magnetic resonance imaging protocols for pediatric neuroradiology. Pediatr Radiol 2007;37:789‑97.
10. Allisy‑Roberts P, Williams J. Hazards and safe practice in MRI. Farr’s Physics for Medical Imaging. 2nd ed. Philadelphia: Saunders, Elsevier;
2008. p. 192‑4.
11. Osborn AG. Brain development and congenital malformation. In: Diagnostic Neuroradiology. 1st ed. St Louis, Missouri: Mosby Year Book; 1994. p. 3‑116.
12. Spalice A, Parisi P, Nicita F, Pizzardi G, Del Balzo F, Iannetti P, et al. Neuronal migration disorders: Clinical, neuroradiologic and genetics
aspects. Acta Paediatr 2009;98:421‑33.
13. Monteith SJ, Yen CP, Sheehan JP. Gamma knife surgery for pediatric arteriovenous malformations: A review. Clin Neurosurg 2011;58:126‑32.
14. Burger PC, Scheithauer BW, Vogel FS. Intracranial meninges. In: Surgical Pathology of the Brain and its Coverings. 4th ed. Philadelphia, PA: Churchill Livingstone; 2002. p. 89‑93.
15. Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TA, Poretti A, et al. Congenital abnormalities of the posterior fossa. Radiographics 2015;35:200‑20.
16. Arachnoid Cyst Imaging. Available from: http://www.emedicine. medscape.com/article/336489‑overview. [Last accessed on 2016 Mar 24].
17. Murthy JM. Intracranial arachnoid cysts: Epileptic seizures. Neurol India 2013;61:343‑4.
18. Berle M, Wester KG, Ulvik RJ, Kroksveen AC, Haaland OA, Amiry‑Moghaddam M, et al. Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults. Cerebrospinal Fluid Res 2010;7:8.
19. Wong WH. Pediatric Neuroradiology: Congenital Disorders of the Brain. Available from: http://www.spinwarp.ucsd.edu/NeuroWeb/ Text/br‑140.htm. [Last accessed on 2016 Nov 18].
20. Kalantari BN, Salamon N. Neuroimaging of tuberous sclerosis: Spectrum of pathologic findings and frontiers in imaging. AJR Am J
Roentgenol 2008;190:W304‑9.
21. Press GA, Nelson MD. Developmental disorders. In: Edelman RR, Hesselink JR, Zlatkin MB, Crues JV, editors. Clinical Magnetic Resonance Imaging. 3rd ed. Philadelphia: Saunders‑Elsevier; 2006. p. 1705‑55.
22. Singh S, Chukwunyere DN, Omembelede J, Onankpa B. Foetal congenital anomalies: An experience from a tertiary health institution in North‑West Nigeria (2011‑2013). Niger Postgrad Med J 2015;22:174‑8.