Brain Computerised Tomographic Findings In Elderly Nigerians With Alzheimer's Disease
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Abstract
The Brain C/T Scan of 56 Elderly Nigerians made up of 20 cases of clinically diagnosed Dementia (Study Group) and 36 Non-Demented cases that are considered free of significant Cognitive impairment (Control Group), were evaluated. The subjects were selected and categorized based on their performance on the screening tests, which consist of both a screening stage and a Clinical assessment stage. The Study group recorded a significant smaller Brain (142.93+/- 91.6) than the Control group (148.6+/-12.7), and is associated with larger Ventricular sizes. No statistically significant Sex difference was established in both Clinical groups studied. The expected Linear Age relationship with Brain size was found to be less applicable in the Dementia study group, which is attributed to the pathology of the Alzheimer's disease (AD). Cortical Atrophy was the predominant Brain C/T changes found in both Clinical groups studied, but they are more pronounced, though not statistically significant, in the Dementia group. The statistically significant lower MMSE (11.6+/-5) recorded in the Dementia group shows that a significant relationship exist between level of cognitive deterioration and C/T indices of Brain Atrophy.
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